The Chinese Communist Party has been concealing and downplaying the severity of the CCP-virus. As five witnesses, including hands-on researchers and a military official, have fled China to testify against the CCP, the Chinese state media has to gradually change its story.
The original news article first appeared on Health News Network with the title: “Breaking news! Novel coronavirus was widely spreading in the population very early on”.
The joint research team, led by Professor Lu Hongzhou from Shanghai Public Health Clinical Center and Academician Chen Saijuan from National Major Scientific and Technological Infrastructure for Translational Medicine (Shanghai), conducted a comprehensive and in-depth analysis of the clinical symptoms, immunoassays, and virological data of 326 patients with new coronavirus pneumonia admitted at the Shanghai Public Health Clinical Center between January 20 to February 25, 2020. Their study found that the pathogens have been widely present in the population from the end of 2019 to the beginning of this year.
At the time of the outbreak, the South China Seafood Market in Wuhan was not the source. The pathogen was likely to spread independently from multiple branches of a common ancestor earlier, which eventually led to the outbreak. Their study was published in the online version of “Nature” magazine on May 20.
The research team completed the sequencing, assembly and analysis of 112 new coronavirus genomes with high quality. The evolutionary tree analysis of the viral genome sequence revealed that the new coronavirus mainly has two branches of Clade I and Clade II. The study confirmed that the 6 patients with a history of exposure to the South China Seafood Market were all concentrated on the Clade I branch, while Clade II patients had no such history. This result suggests that the occurrence of the New Coronary Pneumonia epidemic is not limited to the South China seafood market.
After that, the research team conducted a comparative analysis of the variation characteristics of the new coronavirus gene sequence (as of early March 2020) in patients at different time stages and in different regions of the outbreak. The virus genome isolated from the Shanghai case identified 169 base changes, and its repeated mutations were consistent with the published virus sequence, showing a relatively stable evolutionary process. This result suggests that the new coronavirus may have adapted to spread in human hosts early in the outbreak.
The research team also found that the lymphocytes of patients with neocoronavirus pneumonia were significantly reduced, especially the CD4 + and CD8 + T lymphocytes in severe patients were the most obvious. The level of lymphocyte decline is closely related to the severity of the disease, and severe patients are closely related to the marked increase in the levels of inflammatory cytokines (IL-6 and IL-8).
This indicates that the severity of the new coronavirus pneumonia disease is mainly related to the patient’s age, underlying disease, lymphopenia and related cytokine storms. Based on the analysis of the above clinical data, early targeted interventions will help stop the disease.
Link to the study published on Nature on May 20: